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KMID : 0363320100310020242
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Journal of Korean Oriental Internal Medicine
2010 Volume.31 No. 2 p.242 ~ p.253
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Research on Anti-inflammatory Effects of Forsythiae Fructus
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Chu Cheng-kang
Jung Sung-Ki
Jung Doo-Young
Kim Jin-Ju
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Abstract
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Objectives : The purpose of this study was to examine the anti-inflammatory effects Forsythiae Fructus on LPS-activated RAW264.7 cells.
Methods : Statistical significance was examined through measuring MTT, nitric oxide (NO), TNF , IL 6, NOS2 and COX2 of LPS-activated RAW264.7 cells.
Results : In the toxicity experiment of FFE, NO significant toxicity was shown on cells in the concentration ranges of 100, 200 and 300 . FFE dose dependently decreases 5.49, 25.41, 33.64 % in LPS induced NO production (p<0.05, p<0.001 and p<0.001), however, FFE don’t show significant difference in LPS-induced TNF and IL 6. Furthermore, FFE showed inhibiting tendency against the revelation of NOS2 and COX2 in LPS-activated RAW264.7 cells, dose-dependently according to concentration.
Conclusions : These results mean that FFE is effective for anti-inflammation via inhibition of NOS2 and COX2 expression.
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KEYWORD
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Forsythiae Fructus, MTT, NO, TNF , IL 6, NOS2, COX2
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